The Covaris S2 Adaptive Focused Acoustic Disruptor enables improved preparation of small biological samples up to 100ul in volume, larger volumes are accommodated with larger vessels. Its capabilities include DNA and chromatin shearing, tissue disruption and homogenization, and cell lysis among others. The benefits of this method of preparation compared to standard sonication and homogenization techniques are: Isothermal processing which minimizes heat damage. Non-contact, closed vessel processing eliminates cross contamination problems. Precisely controlled energy delivery allows standardized, highly reproducible processing of samples. The CryoPrep is a microprocessor controlled hammer and anvil mechanism. In practice, it is an electronic solenoid developed to deliver controlled, repeatable mechanical energy (i.e., impact force) to a sample.