Long reads is key for de novo genome assemblies, detection of structural variant and single molecule sequencing. The Megaruptor®was designed to provide researchers with a simple, automated, and highly reproducible device for the fragmentation of DNA from 3kb - 75kb. Shearing performance is independent of the source, concentration, temperature, or salt content of a DNA sample. User-friendly software allows for two samples to be processed sequentially without additional user input. Just set the desired parameters and the automated system takes care of the rest. The disposable hydropores eliminate clogging issues, prevent cross-contamination and ensure the most dense size distribution.